In this study, BKM120 slightly reduced the phosphorylation of mTOR at the Ser2448 residue, which regulates the binding of raptor and rictor to mTOR [50], and inhibitors of both PI3K and mTOR blocked Akt phosphorylation more completely, which resulted in improved radiation sensitization in HCC cells. This evidence concerns the gene RICTOR and hepatocellular carcinoma.