The role of rVP1-mediated decrease of COX-2/PGE2 and MIG-7 in inhibiting tumor growth and metastasis of lung adenocarcinoma was further substantiated by analyzing COX-2/PGE2 and MIG-7 in the lung cancer xenograft mice with or without rVP1 treatment. The gene discussed is PTGS2; the disease is lung cancer.