AKT1 and lung cancer: Recently COX-2/PGE2 has also been found to induce migration inducing gene-7 (MIG-7) protein that sustains the activation of PI3K/Akt/glycogen synthase kinase-3 β (GSK-3β) signaling via decreasing the activity of protein phosphatase 2A (PP2A) to increase lung cancer invasion/metastasis [12].