PTGS2 and lung cancer: We found that overexpression of ILK by transfection of ILK plasmid (pILK) in H1299 and CL1-5 lung cancer cells increased phosphorylation of AktS473, IKKα/βS176/180 and NF-κB p65S536 as well as degradation of IκB, which were positively correlated with elevation of COX-2 level (Figure 3C and 3D).