GFAP and diabetes mellitus: Since a reduction of GFAP-expression in retinal astrocytes and an increase in Müller cell GFAP levels during diabetes were linked to a reduced ability to maintain BRB integrity [31], [32], it seems likely that changes in GFAP-immunoreactivity in Müller cells and astrocytes could be involved in Evan's blue leakage in eyes from SE-housed diabetic rats, and for the preservation of BRB integrity induced by EE.