Furthermore, CAMK2N1-mediated inhibition of CAMKII activity caused deactivation of MEK/ERK kinase activity and accumulation of p27 protein, which primarily regulates the cell cycle progression of colon cancer cells [7, 8], suggesting a role of CAMK2N1 in tumorigenesis. This evidence concerns the gene CAMK2N1 and malignant colon neoplasm.