LDHA and neoplasm: As a result of these events, markedly decreased or depleted BCSCs/iBCSCs were detected using in vitro and in vivo-based assays, namely ALDH activity as a marker (Fig. 1A), mammosphere formation (Fig. 1B, D, Fig. 2C), tumorigenicity in vivo (Fig. 1C), mammosphere formation of digested primary tumor cells (Fig. 3E, F) and spontaneous lung metastasis (Fig. 4A).