We further determined whether the P5 and P6 peptides inhibited VEGFR-3 phosphorylation, cell migration and invasion in various cancer cell lines (breast cancer cell lines: MDA-MB-231, BT474, HS578T, HBL100, MDA-MB-361, and MCF-7; lung cancer cell lines: CL1-5, H460 and H322) (Figure 4B-4E and Supplemental Figure S4). This evidence concerns the gene FLT4 and breast carcinoma.