To evaluate the potential of MMP12 gene-modified ECFCs as regard to uPAR-dependent tumor invasion and angiogenesis we performed A375 Matrigel invasion and capillary morphogenesis of control human microvascular endothelial cells (HMVEC) in the presence of CM ECFC-MMP12 or CM ECFC-MOCK. Here, MMP12 is linked to neoplasm.