CDH1 and hepatocellular carcinoma: In addition, treatment of PRL-1 stably-transfected HCC cells (Huh7) with PI3K inhibitor ZSTK474 remarkably repressed activities of phosphorylation of AKT at ser474, restored GSK-3βactivities, inhibited Snail expression, rescued the expression of E-cadherin, as well as repressed cells migration and invasion.