Our study screened 576 miRNAs from miRNome microRNA Profilers QuantiMirTM kit and found miR-519d most down-regulated in response to CTGF overexpression; miR-519d reportedly suppresses tumor formation in human hepatocellular carcinoma, making it an attractive candidate biomarker for prediction of anticancer treatment response [51, 52]. Here, CCN2 is linked to hepatocellular carcinoma.