TLE1 and lung carcinoma: This preliminary finding, in conjunction with the recent evidence documenting that TLE1 may function as a lung specific oncogene [16], has prompted us to investigate the significance of the Bit1 apoptotic pathway in the anoikis insensitivity and tumorigenic potential of Non Small Cell Lung Carcinoma (NSCLC), which is the most aggressive form of lung cancer and is highly chemoresistant in part due to a deficient caspase-dependent apoptosis pathway [17], [18].