Biochemical analysis of this phenomena showed that the expression of the β4GalNAcT3 gene results in the activation of focal adhesion kinase and of extracellular signal-regulated kinases, indicating that this enzyme plays a critical role in promoting malignant behaviors of human colon cancer through the integrin-mediated signaling pathway [38]. The gene discussed is B4GALNT3; the disease is malignant colon neoplasm.