CENPF and breast cancer: Moreover, a careful analysis of the three network hub genes (PTTG1, PRC1, and CENPF) reveals that PTTG1 is linked to tumor malignancy and has been proposed as a possible therapeutic target (62); PRC1 encodes a factor responsible for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly, and has been involved in the growth of breast cancer cells (63, 64); and that CENPF encodes a protein that associates with centromere and kinetochore complexes.