AGRP and Huntington disease: Compared to the BLSA control group (21.48 ± 1.18 pg/mL), pre-manifest HD subjects showed a significant increase in circulating AgRP (33.28 ± 3.05 pg/mL, p = 0.007) (Figure 1C), and the same trend was also observed when compared to the familial controls (25.14 ± 1.60 pg/mL, p = 0.056).