Reduced GH and prolactin levels suggest that the HD patients may possess a dysfunctional hypothalamic-pituitary system (Phelps, 1994; Phelps and Hurley, 1999), which potentially affects food intake and energy balance, leading to further weight loss and energy insufficiency (Gerardo-Gettens et al., 1989; Auffret et al., 2012). Here, GH1 is linked to Huntington disease.