Bush et al. (on the basis of the studies done by them and others) have proposed that a number of proteins involved in neurodegeneration (Aβ, AβPP, tau, presenilin, and β-secretase1) fail in their ability to regulate metals in the AD brains (Finefrock et al., 2003; Bonda et al., 2011; Bush, 2013), and consequently these proteins are overwhelmed by the increased levels of these metals. The gene discussed is APP; the disease is Alzheimer disease.