Therefore, we observed the changes in liver cancer cell’s invasion, proliferation, apoptosis and cell cycle; and the changes in MAPK signal pathway-related proteins (p-P38, p-ERK1/2, p-JNK and VEGF-C) after BMPR-II silence to explore the biomechanism that BMPs affect liver cancer’s invasion, proliferation and metastasis. The gene discussed is CLN5; the disease is liver cancer.