Stressful stimuli increase levels of SP and Tac1 mRNA within the amygdala regions of restrained rodents (Ebner et al., 2004; Sergeyev et al., 2005) an observation reminiscent of patients diagnosed with stress disorders (Geracioti et al., 2006) or those placed in anxiety inducing situations who have elevated levels of SP in their cerebral spinal fluid (Michelgard et al., 2007). Here, TAC1 is linked to Anxiety.