Because of the known role of TAC1 in anxiety related behaviour and the ability of the Tac1 gene to respond to both stress (Ebner et al., 2004; Sergeyev et al., 2005) and Dex in primary amygdala cell culture, we investigated whether the human TAC1 promoter was responsive to Dex in primary amygdala cells using pTAC1prom-Luc that will be subsequently referred to as pTAC1promG-luc to reflect the specific genotype at the rs17169049 locus (discussed later). This evidence concerns the gene TAC1 and Anxiety.