MBD5 and Global developmental delay: In addition, microduplications in the same region have been associated with autistic or Angelman-like features and developmental delay, suggesting that either decreases or increases in expression of wild-type MBD5 can result in clinical phenotypes (Chung et al, 2011; Bonnet et al, 2013; Mullegama et al, 2014), further highlighting the relevance of a functional characterization of MBD5.