PLA2G7 and atherosclerosis: Recent data confirm the involvement of Lp-PLA2 in the development of atherosclerosis by modifying the affinity of LDL particles for extracellular matrix proteins.30-32 Moreover, Lp-PLA2 favours lipid accumulation in arterial walls, lipid peroxidation, and hydrolysis of lysophospholipids and free fatty acids.33,34 Lp-PLA2 may be identified as an independent risk factor for rupture of atheroma plaque and thrombo-embolic events.12