F7 and cardiovascular disorder: There are sufficient data concerning the association of D-dimer, coagulation factor VII, von Willebrand factor and fibrinogen levels with the risk of coronary heart disease in women (after statistical adjustments for traditional risk factors).21 Studies demonstrated the presence of high levels of coagulation factor VII in women suffering from angina or other cardiovascular diseases.22-25 However, the most eloquent reports support the use of D-dimer in estimating prognosis of cardiovascular death and other events in women.26