CRP levels in women are higher than in men, especially during puberty.2 The JUPITER trial reported that an hs-CRP value over 2 mg/dl in association with a low-density lipoprotein (LDL) cholesterol value below 130 mg/dl in women without cardiovascular pathology increases the risk of cardiovascular events.12 Moreover, high levels of CRP in women without cardiovascular disease are important predictors for the development of fatal heart attack and stroke.13 This evidence concerns the gene CRP and Stroke.