Furthermore, reduced levels of OGT and OGA might not normally regulate dynamic O-GlcNAcylation during the cell cycle, which is required for cell cycle control.15, 16 We conclude that O-GlcNAc enzymes are essential for tumor growth in CRC, and that targeting OGA may help suppress the intestinal tumorigenesis initiated by Apc mutation. This evidence concerns the gene APC and neoplasm.