OGT and colonic neoplasm: Several studies have suggested that the O-GlcNAcylation of β-catenin affects its transcriptional activity and subcellular localization.12, 18 Moreover, higher levels of O-GlcNAcylation and OGT expression are found in colon tumors than in corresponding non-tumorous mucosal tissues.2 Although current evidence implicates O-GlcNAcylation in CRC, it remains unclear exactly how the levels of O-GlcNAcylation or O-GlcNAc cycling enzymes affect colorectal tumorigenesis.