Although the mechanism by which COX-2 and iNOS are up-regulated and over-activated in most cancer cells remains not clear enough, it was reported that their expressions were transcriptionally controlled by the binding of multiple transactivators such as c-Jun, C/EBPβ and NF-κB and coactivators such as p300 to the core promoter regions [46]. This evidence concerns the gene CEBPB and cancer.