Although the underlying molecular mechanism of antitumor activity for melanoma has not been fully elucidated, various studies in vivo and in vitro demonstrated that it might be partially realized through inhibitions of MMP-9 and NF-κB [22], blocking HIF-1α, STAT3 signaling and VEGF expression [23], regulating the transcription of cell proliferation-related genes, such as Nestin, Bmi-1 and Sox2 [24], suppressing the expression of 45S pre-ribosomal RNA and upstream binding factor [25]. This evidence concerns the gene NFKB1 and melanoma.