Abu-Maziad et al.[8] investigated three of the four SNPs evaluated in this study and found that they had no effect, whereas Michalek et al.[37] reported a negative association between BPI SNPs and sepsis in children aged 0–18 years in so far as GG genotype (rs4358188) of BPI and AG genotype (rs 5743507) were associated with increased susceptibility to severe sepsis and a negative outcome. This evidence concerns the gene BPI and Sepsis.