Genotypes CT and TT of IL1β-rs1143643 and GG of MMP-16-rs2664349 were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of BPI-rs4358188 and CT of DEFβ1-rs1799946 were associated with a significantly reduced risk (p = 0.05 for both). This evidence concerns the gene DEFB1 and Sepsis.