Moreover, the rs2664349 SNP not only seems to influence the pulmonary expression and function of MMP-16 and the risk of bronchopulmonary dysplasia in premature infants, but also the activation of MMP-2 [35], an MMP that plays a central role in monocyte chemoattraction and, consequently, in the response to infectious agents. This evidence concerns the gene MMP16 and bronchopulmonary dysplasia.