In the current study, our data show that NRP1 could have a role in the regulation of proliferation and drug resistance in OSCC, implicating NRP1 as a potential promoter for some CSC-like properties in mesenchymal cells, which is in accordance with the conclusions of Glinka et al. [32] in breast cancer stem-like cells and of Beck et al. [41] in cutaneous CSCs. This evidence concerns the gene NRP1 and breast carcinoma.