Enhanced expression of Wnt5a may induce the nuclear accumulation of β-catenin and activate the canonical Wnt signaling pathway, thus leading to the upexpression of VE-cadherin, MMP2, and MMP9, then resulting in angiogenesis, and ultimately promoting the growth and metastasis of NSCLC. The gene discussed is CDH5; the disease is non-small cell lung carcinoma.