Docetaxel, a semisynthetic analog of paclitaxel, is one of the first-line chemotherapy regimens for advanced NSCLC, with genotoxic effects caused by microtubule stabilizing, apoptotic induction through microtubule bundling, and Bcl-2 blocking [99, 100]. The gene discussed is BCL2; the disease is non-small cell lung carcinoma.