TP53 and cancer: The tumor suppressor p53 gene regulates cell growth through the activation of the transcription of numerous genes specifically those involved in cell cycle regulation, apoptosis, and genomic stability [132–134] andhas also been implicated in the response to anticancer therapies [133]. p53 has been reported to be frequently mutated in humans cancers with mutations occurring in greater than 50% of lung tumors [135, 136].