4-HNE increased PPAR-γ gene expression and accelerated adiponectin protein degradation in adipocytes [263]; expression of PPAR-γ was induced in HL-60 and U937 cells by 4-HNE treatment [264], whereas in the colon cancer cell (CaCo-2) PPARγ protein expression was not induced after 4-HNE treatment [265]; 4-HNE increased PPARγ2 expression in C2C12 cells [266]. This evidence concerns the gene PPARG and colonic neoplasm.