Murine 005 GBM cells, possessing heterozygous Tp53 and activated Ras and Akt, exhibit stem-like properties, including high-level expression of mProminin-1 (CD133 equivalent), and demonstrate histopathological hallmarks of GBM such as cellular heterogeneity, invasion and hypervascularity (Marumoto et al., 2009). The gene discussed is PROM1; the disease is glioblastoma.