PSMD10 and hepatocellular carcinoma: As shown in Figure 2, Gankyrin expression progressively increased as follows: normal liver < chronic hepatitis < cirrhosis < AH and HCC tissues (corresponding to the sequential stages of hepatocarcinogenesis); this pattern was observed in cytoplasmic, nuclear, and total cellular expression (P = 4.78 E-016, P = 9.70 E-096, and P = 9.45 E-052, respectively).