Obesity-associated insulin resistance is a major risk factor for type 2 diabetes,18 and fat accumulation has been reported to be associated with systemic oxidative stress19,20; therefore, it may be possible to assess the risk of diabetes based on the association between the Ser326Cys hOGG1 polymorphism and body mass index (BMI). This evidence concerns the gene OGG1 and type 2 diabetes mellitus.