ANKS6 has been linked to Bicaudal-C1 (BICC1), a protein that when mutated is responsible for disease in the jcpk mouse model of ADPKD and the bpk mouse model of ARPKD (autosomal recessive polycystic kidney disease) [41,42]. The gene discussed is BTK; the disease is autosomal recessive polycystic kidney disease.