Furthermore, tumors with expression of HLA class I showed significantly more Foxp3+ cells above median compared to tumors with loss of HLA class I expression (p < 0.001).The presence of Foxp3+ cells above median in the tumor microenvironment was significantly related to a better OS (logrank p-value <0.001) and DFS (logrank p-value <0.001) with HR’s of 0.637 (95% CI 0.500-0.813, p < 0.001) and 0.624 (95% CI 0.491-0.793, p < 0.001) respectively in case of presence of Foxp3+ cells above median compared to Foxp3+ cells below median (Figure 3). The gene discussed is FOXP3; the disease is neoplasm.