These data supported decreased miR-200c expression in NSCLC was associated with advanced clinical stage, lymph node metastasis.Next, we investigated the expression levels of USP25 in these patients, the results revealed higher mRNA levels of USP25 were found in NSCLC tissues than non-tumor tissues (Figure 7E), correlated with distant metastasis, and clinical advanced stage (Figure 7F,G). This evidence concerns the gene USP25 and neoplasm.