The genetic characterization of DSRCT is a chromosomal translocation of t(11; 22) (p13;q12) between the Ewing’s sarcoma (EWS) gene on chromosome 22 and the Wilms’ tumor (WT1) gene on chromosome 11, leading to a EWS-WT1 fusion transcript. The gene discussed is EWSR1; the disease is sarcoma.