INS and Insulin resistance: At equivalent time in insulin‐resistant rats gavaged with water, the effect of insulin on blood glucose concentration was not as marked (mmol/L ± SE at T0 and T15: 8.8 ± 0.2 and 5.8 ± 0.5, compare Fig. 5A to Fig. 3C), confirming the efficacy of the high‐fat diet in inducing insulin resistance.