Majority of the studies on insulin resistance typically focus on glucose metabolism, even though insulin also regulates protein synthesis and/or breakdown (Marliss and Gougeon 2002), especially in skeletal muscle of rodent (Wang et al. 2006; Kimball and Jefferson 2010) and human whole body studies (Halvatsiotis et al. 2002; Pereira et al. 2008). Here, INS is linked to Insulin resistance.