IL6 and obesity due to melanocortin 4 receptor deficiency: Obesity has been characterized as a state of chronic low‐grade inflammation, due to the increased secretion and subsequent ~2‐ to 3‐fold elevation in systemic inflammatory markers, including tumor necrosis factor‐α, interleukin‐1β (IL‐1 β), and interleukin‐6 (IL‐6) (Kern et al. 2001; Weisberg et al. 2003).