KSR2 and Obesity: KSR2 mutations in humans (Pearce et al. 2013) recapitulate the obesity and severe insulin resistance observed in C57BL/6 ksr2−/− mice (Costanzo‐Garvey et al. 2009), revealing them as a disease‐relevant model system, allowing investigation into mechanisms through which KSR2‐dependent signaling may contribute to the onset and progression of obesity and diabetes in humans.