In combination with the defective activation of AMPK of adult ksr2−/− mice, this observation is consistent with recent observations that AMPK protects against hepatic steatosis by phosphorylating SREBP‐1c, suppressing its cleavage and nuclear translocation, and repressing expression of SREBP‐1c target genes that promote lipogenesis and lipid accumulation (Li et al. 2011). The gene discussed is SREBF1; the disease is fatty liver disease.