MMP2 and hepatocellular carcinoma: As shown in Figure 4C, serum soluble CD147 and secreted MMP-2 levels were significantly higher in HCC patients than in healthy individuals (P < 0.001) (CD147: HCC, median 4.483 ng/ml, range 2.218–20.820 ng/ml; healthy, median 2.811 ng/ml, range 1.956–5.260 ng/ml.