The secretion of β-hexosaminidase is the hallmark of mast cell degranulation, and histamine, IL-6, IL-13 and TNF-α are typical cytokines secreted after mast cell activation: Histamine is an important mediator in the initiation and the development of antigen-induced airway responses, IL-6 contributes to the pathogenesis of asthma [19], IL-13 is needed for IgE formation and TNF-α is amplified the inflammatory response [20,21,22,23]. This evidence concerns the gene IGHE and asthma.