STAT3 and Familial prostate cancer: Specifically, gene transfer of wild-type STAT3 was found to promote the rearrangement of actin stress fibers and microtubules, and facilitates the formation of lamellipodia in prostate cancer cells [142,143]; in the same studies, it was demonstrated that enforced expression of STAT3 can increase cell migration in vitro, and substantially enhance lung metastasis in vivo [142,143].