Loss of SHP-1 has been shown to directly contribute to the constitutive activation of STAT3 in these cancer types, including ALK-positive anaplastic large cell lymphoma, chronic myeloid leukemia and multiple myeloma, since gene transfection of SHP1 in these cells can substantially decrease the level of STAT3 activation [49,52,53,54]. The gene discussed is STAT3; the disease is plasma cell myeloma.