Recently, somatic mutations in STAT3 were discovered in hepatocellular adenomas and many types of hematopoietic malignancies, such as T-cell large granular lymphocytic leukemia (T-cell LGL), chronic lymphoproliferative disorders of natural killer cells (CLPD-NKs), diffuse large B-cell lymphoma, and CD30+ T-cell lymphomas [89,90,91,92,93,94,95]. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.