STAT3 is also known to be highly activated in ALK-positive anaplastic large cell lymphoma by the oncogenic fusion protein, NPM-ALK, a constitutively active tyrosine kinase resulted from the specific chromosomal translocation that fuses the anaplastic large cell lymphoma kinase (ALK) gene on 2p23 to the nucleophosmin (NPM) gene on chromosome 5q35 [64,65]. The gene discussed is STAT3; the disease is anaplastic large cell lymphoma.