We made a conditional deletion of STAT3 in IEC of these mice (Apcmin/+/Stat3IEC-KO mice) to investigate the role of STAT3 in CRC and found an anti-carcinogenic role for STAT3 [15], which was unexpected given a plethora of literature supporting the pro-oncogenic role of STAT3. Here, STAT3 is linked to colorectal carcinoma.