In contrast to TSH, the plasma nesfatin-1 level in the T2DM group was significantly lower than in the groups of IGR and controls (0.73 ± 0.14 versus 1.12 ± 0.39 versus 1.00 ± 0.23 ng/mL, both P < 0.01) (Figure 1). This evidence concerns the gene NUCB2 and type 2 diabetes mellitus.