Upregulation of FSP1, Col1a1, and Vim has been implicated in renal fibrosis and the downregulation of the antifibrotic BMP4 and BMP7 confirmed the fibrosis establishment, while central role of TGF-β in human and experimental models for renal fibrosis has been well described [3, 4, 17, 18]. The gene discussed is S100A4; the disease is renal fibrosis.