NQO1 mRNA levels were unchanged in CRPC relative to normal prostate or primary prostate carcinoma (data not shown) and there was no significant correlation between NQO1 mRNA and AKR1C3 mRNA expression in CRPC patients (R2 = 0.02; Pearson product-moment correlation; Figure 2B). This evidence concerns the gene AKR1C3 and prostate carcinoma.