AKR1C3 and breast cancer: A similar meta-analysis was conducted across seven breast cancer datasets that included normal breast samples, showing that AKR1C3 mRNA expression is significantly downregulated in breast cancer samples relative to normal breast tissue (P < 0.001; one-way ANOVA with Dunnett’s multiple comparison analysis; Figure 2C), including in paired samples from post-menopausal ER-positive breast cancer patients (P < 0.0001) (Figure 2D).