Our study establishes the following findings: 1) In a cohort of human subjects without known coronary artery disease and cholesterol levels that span the normal and hypercholesterolemic range, CX3CL1, GM-CSF, and VEGF-A levels are significantly reduced by multiple statin therapies (atorvastatin, pravastatin and rosuvastatin). Here, CSF2 is linked to coronary artery disorder.