An additional feature of CaMKII-dependent arrhythmia in heart failure and AF, and probably in acquired disease in general, is the importance of CaMKII-oxidation as a source of kinase hyperactivity (Luczak and Anderson, 2014; see also the review by Erickson, 2014 in this special issue). The gene discussed is CAMK2G; the disease is Arrhythmia.