An example of the importance of such integrative analysis is shown by Wang, et al. where the corroboration of genomic aberrations at the protein level has been demonstrated with KRAS in pancreatic cancer in which targeted MRM-MS approach coupled with immunoprecipitation of intact RAS protein isoforms detected a single point mutation at the peptide level in KRAS oncogenes from a cell line, tumor sample and pancreatic cyst fluid at sensitivity of <25 fmol/mL [78]. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.