Using multiple linear regression [15], we showed that in girls with untreated idiopathic central precocious puberty, the difference between the AH and TH (1.7 ± 4.3 cm) can be predicted at an initial evaluation as follows: 2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R = 0.88. Here, PLOD1 is linked to central precocious puberty.