Dasatinib treatment of TBP-3743 cells reduced pAKT levels, perhaps permitting apoptosis, whereas the high basal pAKT levels in the PTEN-null cells were unaffected by dasatinib treatment, suggesting that the loss of PTEN and the concomitant increase of AKT signaling may be a factor influencing resistance to apoptosis following BRAFV600E-inhibition as has been demonstrated in melanoma [62]. The gene discussed is PTEN; the disease is melanoma.