BCL2 and neoplasm: Since conventional MAPKs activation has been shown to promote the expression and phosphorylation of pro-apoptotic Bax, and to disrupt anti-apoptotic Bcl-2 function, thereby resulting in apoptosis [20,28,29], it is reasonable to assume that Bax and Bcl-2 may act downstream of MAPKs activation to induce apoptosis in tumor cells treated with DHA.