Studies showing that the blockade of RAS by angiotensin-converting enzyme (ACE) inhibitor captopril or angiotensin II type 1 receptor blocker (ARB) losartan between 2 and 4 weeks of age offsets the effects of nutritional programming on BP and were supportive of the role of RAS, linking maternal malnutrition to adulthood hypertension [37,38]. This evidence concerns the gene ACE and hypertensive disorder.