PTGS2 and cancer: In addition to cancer metastasis, a similar signal pathway has also been reported in the berberine reduced integrin expression and cell migration in chondrosarcoma cells, which inhibited the PKCδ and c-Src pathways [26], prostaglandin E2 regulated oral cancer migration, which involved PKCδ-dependent c-Src pathway [36], and COX-2 promoted cancer metastasis, which mediated PKCδ and c-Src pathways [37].